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First, GSH synthesis in mammalian cells requires 3 genes (GCLC, GCLM and GS) that encode the GCL holoenzyme and glutathione synthetase 23

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Although the role of NKCC2 in renal handling of glucose remains poorly defined, NKCC2A KO mice developed several aspects of MetS including increased basal glycemia, glucose intolerance and insulin resistance (Kelly et al., 2019), but not hypertension, at least when mice were young (Oppermann et al., 2007)

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