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Some people report that reduced food reward is accompanied by a broader flattening of pleasure or motivation

Acting as a growth factor, insulin signaling activates the MAP kinase (MAPK) pathway either through insulin receptor phosphorylation of SRC homology 2 domain-containing protein 1 (encoded by the SHC1 gene) which then interacts with growth factor receptor binding protein-2 (GRB2) or via IRS1 activation

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