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Coffee, particularly the morning cup, stimulates colonic contractions through multiple mechanisms

Biology of incretins

Abrupt discontinuation without medical guidance may lead to deterioration in glycaemic control if you have diabetes, or weight regain if prescribed for obesity management

A major open question at this point is how the spending impact of these drugs might compare to the avoided cost of alternative treatments

Based on the known class profile of GLP-1 and glucagon receptor agonists, the following additional risks are relevant: Pancreatitis: Severe and persistent abdominal pain, particularly if it radiates to the back and is accompanied by vomiting, may indicate pancreatitis