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Wen H, Niu X, Hu L, Sun N, Zhao R, Wang Q

107 GSTM1 and GSTT1 activity is variable in motor impairment among those with the active gene, suggesting a cumulative effect that may not be evident in the early stages of the disease

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[2] Systemically, angiogenic activity is a double-edged property in principle helpful for perfusing regenerating tissue, but something that any candidate with pro-angiogenic signaling must be evaluated against carefully in other contexts, including any setting where promoting blood-vessel growth would be undesirable