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Vegans, vegetarians, and pregnant women should be especially concerned about vitamin B12 deficiency

Current limitations include: limited long-term safety data compared with established medicines trial populations that may not represent broader real-world groups evolving phase 3 research ongoing monitoring of adverse events the need for longer follow-up across different study populations This does not make the available data unimportant

doi:10.1016/j.freeradbiomed.2008.10.040

However, patients with liver or kidney disease should avoid early dosing and consult their provider before adjusting any schedule

Think of it like a key fitting into a lock and turning it

Van der Heiden A, Harrison L, Warshauer J, Li X, Adams-Huet B, Lingvay I