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In different rodent models, liraglutide seems to positively influence bone material properties despite notable weight loss

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Decorin plays an important role in the regulation of collagen fiber organization and function within the extracellular matrix

For example, treatment of murine macrophages with GLP-1RAs in vitro inhibits monocyte chemoattractant protein-1 gene expression and p65 as well as tumor necrosis factor (TNF)- expression