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Assessing the requirement of CD36 for GLP-2-mediated increases in intestinal-TG secretion are complicated by the increased fatty acid absorption (as shown by appearance of radiolabel in plasma), TRL-TG and TRL-apoB48 secreted by Cd36 / mice compared to wild-type controls (Hsieh et al., 2009)

Safety and efficacy of combination therapy with semaglutide, cilofexor and firsocostat in patients with non-alcoholic steatohepatitis: a randomised, open-label phase II trial

SOURCE: Lilly INVESTOR

Yet for many patients, progress is incomplete

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Laparoscopic sleeve gastrectomy differentially affects serum concentrations of FGF-19 and FGF-21 in morbidly obese subjects