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Guideline Statements DIAGNOSIS Guideline Statement 1 The basic assessment should include a careful history, physical examination, and laboratory examination to document symptoms and signs that characterize IC/BPS and exclude other disorders that could be the cause of the patient's symptoms

Bentley, 1990)

These elevated rates occurred primarily during the rapid dose-escalation phase used in Phase 2 trials

They are suitable for the treatment of: Fatigue and lethargy

Patients with a clinically diagnosed B12 deficiency such as pernicious anaemia should be under GP care for ongoing management

Jourdain P, Jondeau G, Funck F, Gueffet P, Le Helloco A, et al