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Gene expression analysis of murine and human osteoarthritis synovium reveals elevation of transforming growth factor beta-responsive genes in osteoarthritis-related fibrosis

Two oral GLP-1s have now received FDA approval: Novo Nordisks WEGOVY pill (December 2025) and Eli Lillys FOUNDAYO (April 2026)

PMID: 29138605

The mechanisms already discussed, including enhanced angiogenesis, increased fibroblast activity, collagen synthesis upregulation, and improved cell migration, all contribute to faster resolution of tissue damage

Two compression injuries were generated per mouse (over the left and right hemispheres)

the Wellcome Trust [Research Training Fellowship WT096002/Z/11/Z] (supporting LP)