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Several factors have contributed to the rise of compounded semaglutide, particularly during the recent drug shortage that lasted from 2022 until February 2025: 1

It's a good idea to call your pharmacy ahead of time to ensure your prescribed dose is in stock

[1] [2] It is given as a once-weekly subcutaneous injection

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It can be stored in many areas like the muscles, heart and brain, but it is manufactured by the kidneys and liver