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Given the increased risk of HDP in pregnant women with MTHFR TT genotype, and the blood pressure-lowering effect of riboflavin in non-pregnant adults with this genotype, it is worth exploring further whether targeted supplementation with riboflavin in pregnancy has benefits as an effective preventive strategy to reduce the risk of HDP and decrease the burden of related adverse pregnancy outcomes in genetically at-risk women

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Most roe samples demonstrated low levels of 4-hydroxybutyric acid, from 0.31 mg/g in roe of female crab Charybdis natator (CNF) up to 1.5 mg/g in red caviar (RCV)

Zhao et al., 2009)