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Appetite hormones shift, satiety signals change, energy expenditure adapts, cravings can intensify, and the brains reward pathways do what they were designed to do: push you back toward your prior weight

Fluids drop because thirst is also less noticeable

and compromised epigenetic regulation of gene expression

Woodward (1973)"

In obese patients undergoing bariatric surgery, a single, low dose of KET (0.5 mg/kg) at induction of anesthesia determined a very fast (hours) amelioration of post-operative depression and pain and an opioid-sparing effect

Consult your GP before combining these products if you have underlying gastrointestinal conditions, are immunocompromised, have diabetes requiring insulin or sulfonylureas, or take multiple medications