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For one, hyperhomocysteinemia has been known to be associated with insufficient stimulation of CBS activity (Selhub et al., 12 deficiency, methionine block implies that SAM (driven by Met) is lowered as well and hence it is plausible CBS is less effective

"Lipoic acid biosynthesis defects"

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doi:10.1016/b978-0-12-387042-1.00005-8 Jieru P, Zhang S, Cai L, et al