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To gain insight into potential dependencies on specific metabolic pathways, the cell lines were then exposed to various metabolic inhibitors with or without MAPK pathway inhibition (Fig

Nausea and appetite sensations were evaluated at the same intervals using 100 mm visual analogue scales [27]

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Supporting Mitochondrial Energy Production Mitochondria are both major producers and targets of oxidative stress

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(PDF) Abbreviations 5,10-methyleneTHF: 5,10-methylenetetrahydrofolate THF: tetrahydrofolate DHF: dihydrofolate dUMP: deoxyuridine monophosphate dTMP: deoxythymine monophosphate 5-methylTHF: 5-methyltetrahydrofolate cSHMT: cytosolic serinehydroxymethyl transferase mSHMT: mitochondrial serinehydroxymethyl transferase MTHFR: methylenetetrahydrofolate reductase TYMS: thymidylate synthase DHFR: dihydrofolate reductase Declarations Conflict of interest The authors have no conflict of interests related to this publication