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Three things matter most in the first 24 weeks: Prep with a high-protein foundation

The risk of new or worsening nephropathy was significantly lower in people taking semaglutide in the SUSTAIN-6 trial

Semaglutide is a GLP-1 receptor agonist that mimics the natural incretin hormone to reduce appetite, slow gastric emptying, and improve blood sugar regulation

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doi: 10.3389/fphar.2025.1618079 Received 28 April 2025 Accepted 08 July 2025 Published 24 July 2025 Volume 16 - 2025 Edited by Karuna Rasineni, University of Nebraska Medical Center, United States Reviewed by Yang Yang, Chinese PLA General Hospital, China Asher Rajkumar Rajan, University of Nebraska Medical Center, United States Updates Copyright 2025 Xie, Yang, Tian and Chen