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Lys(9) for Glu(9) substitution in glucagon-like peptide-1(7-36)amide confers dipeptidylpeptidase IV resistance with cellular and metabolic actions similar to those of established antagonists glucagon-like peptide-1(936)amide and exendin (939)

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Effective plasma concentration can be achieved by oral intake of semaglutide with 120 ml water in fasting state, followed by fasting for another half an hour [41]

Tirzepatide appears to be one of them

Novo Nordisk initiated administrative litigation against this decision and submitted a request for Patent Term Extension (PTE) to CNIPA in 2024

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