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For these assays, increased levels of cAMP were measured as an increase of the 485/535 nm FRET ratio serving as a readout for binding of cAMP to the H188 biosensor that is based on the exchange protein activated by cAMP 15
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As of February 15, 2026, there are no systemic FDA approvals for GHK-Cu for any medical indication, and its uses are largely considered off-label or are in over-the-counter skincare products regulated as cosmetics
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