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The observation that the induced effect on insulin secretion is different when oral glucose was administered versus the same amount of glucose parenterally coined the term incretin effect, supporting the idea that some substances secreted in the intestines favored the release of insulin after ingestion [1]

A pre-clinical study showed that exendin-4 had a remarkable neuroprotective effect, improving the neurological deficit caused by transient middle cerebral artery occlusion in mice, and reducing neuronal loss and microglial inflammation (82)

23 The main focus of this approach is to talk with patients who are initiating therapy about expected AEs, nonpharmacologic counseling, presence of any other GI conditions, and individualizing dose titrations

Its important to recognize that abruptly stopping GLP-1 therapy can lead to common challenges, including weight regain and anxiety about ending treatment

The combination of all three receptors working together produces results that neither single nor dual agonists can match