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The set of behavioral deficits induced after BDNF reduction in the dDG (but not the other sites) such as reduced sucrose preference, home-cage locomotion and activity in the FST can be associated with depressive-like symptoms

Despite all recent progress in dopaminergic drug delivery optimising striatal dopamine substitution through non-invasive oral dopamine replacement strategies remains a priority

J.PadroM.DaemenA.et al (2013)