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Although the exact mechanism(s) by which NAC affected the pathways involved in signal transduction and gene expression cannot be delineated from the results of this study, it is possible that these pathways are regulated by oxidants and redox-sensitive steps since increasing levels of intracellular NAC affect the steady state level of oxidants (Figure 3(c)) and can modify the redox status of the cell (Figure 3), an effect known to exert a regulatory effect on transcriptional activation and gene expression [22, 35, 3840]

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Methods: Patients with a diagnosis of interstitial cystitis were recruited to this study