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Researchers are vigorously studying cell pathways involved in these different states and have made several interesting and surprising discoveries

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42,43,44,45 NAD + is an important regulator of cellular ROS levels that can accumulate upon depletion of NAD +

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Glutathione is widely known as the bodys primary antioxidant, playing a key role in protecting cells from oxidative stress and supporting natural detoxification processes

Differential diagnosis For other causes of 5-oxoprolinuria, beside glutathione synthetase deficiency and 5-oxoprolinase deficiency [9, 29], please see Table 1