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These include serious infection, uremia or renal failure, drugs with bone marrow suppression properties (e.g., chloramphenicol), or concurrent undiagnosed folic acid or iron deficiency anemia

Yes, when supervised

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However, so far, no significant adverse effects have been consistently reported

AGA technical review on the management of moderate to severe ulcerative colitis

Supplementing with vitamin B12 is generally considered safe, as there is a low risk of toxicity