In a study involving patients with CAD and preserved LV function, who were scheduled to undergo coronary artery bypass grafting (CABG), were randomized to receive standard therapy or treatment with GLP-1 (1.5 pmol/kg/min) as a continuous infusion beginning 12 h before CABG and continuing for 48 h after the procedure
This sequence culminates in increased cortisol production by the adrenal cortex
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What happens at the cellular level when doses overlap GLP-1 receptor agonists work by binding to GLP-1 receptors on pancreatic beta cells, neurons in the hypothalamus, and cells throughout the gastrointestinal tract