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One unresolved question in ALS is why the neurons most susceptible to the altered/deficient EAAT2 (and neurodegeneration) come from two different populations which do not have much in common: The lower motor neurons in the spinal cord are cholinergic and project peripherally while the upper motor neurons are glutamatergic, excitatory, reside in the cerebral neocortex and target the brain stem and spinal cord (corticobulbar and corticospinal tracts)

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For example, Lee et al

medRxiv (2023)

For example, individuals with significant liver dysfunction or other medical issues may require a more tailored approach to therapy

Preliminary animal and test-tube studies have noted that GHK-Cu liposomes promoted the proliferation of healthy cells, and increased the rate of scald wound healing in mice [4]