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In the one human trial studying oral BPC-157 for inflammatory bowel disease, approximately 8% reported mild GI symptoms compared to 6% on placebo (Klicek et al., 2012)

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Brown Fat and Thermogenesis Beyond white adipose tissue (the primary fat storage tissue), humans possess brown adipose tissue (BAT) specialized for thermogenesis (heat production)

The nuance is that a large share of autistic patients also show undermethylation traits, where aggressive folate therapy can occasionally activate irritability, anxiety, or sleep disruption