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Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity

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Bethel, M.A., Diaz, R., Castellana, N., Bhattacharya, I., Gerstein, H.C., Lakshmanan, M.C., 2021

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In pancreatic cells, activation of these G proteincoupled receptors primarily signals through pathways involving cyclic adenosine monophosphate (cAMP), protein kinase A ( PKA ), and cAMP response elementbinding protein ( CREB ), thereby enhancing glucose-dependent insulin secretion and supporting -cell function