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Semaglutide is a prescription medication that works as a GLP-1 receptor agonist and is FDA-approved to treat obesity, type 2 diabetes, metabolic dysfunction-associated steatohepatitis (MASH), and to reduce the risk of chronic kidney disease and major cardiovascular events

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This is the same biological principle behind why tolerance develops with many medications

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Alcohol can also trigger hypoglycemia if you're taking insulin or sulfonylureas alongside semaglutide, since your liver's glucose production gets suppressed by ethanol

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