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Protective Effect of Glycyrrhizin on Myocardial Ischemia/reperfusion Injury-Induced Oxidative Stress, Inducible Nitric Oxide Synthase and Inflammatory Reactions through High-Mobility Group Box 1 and Mitogen-Activated Protein Kinase Expression

Our evidences suggested that impaired mitophagy may be a cause of cardiac hypertrophy induced by pressure overload, and semaglutide ameliorated the cardiac hypertrophy by improving mitophagy to suppress the activation of NLRP3 inflammasome (Fig