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Post hoc evaluations of the SUSTAIN 6 trial revealed that semaglutide markedly increased the incidence of diabetic retinopathy complications in individuals with a history of retinopathy, especially among insulin users, presumably due to the swift deterioration of pre-existing retinopathy following rapid glycemic control [91]

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When Zueler injected this preparation into diabetic dogs he encouragingly observed that it significantly reduced the concentration of sugar and ketone, acidic substances produced in the liver resulting from the breakdown of fats, in their urine

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