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Magnesium deficiency is associated with low-grade chronic inflammation involving the proinflammatory cytokines TNF- and IL-1, the messenger IL-6, as well as E-selectins, intracellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1), acute-phase reactants - C-reactive protein and fibrinogen (137)

The joint cartilage samples (all the cartilage on the distal femur) were cut into fine pieces and homogenized after 8 weeks of treatment

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Careful selection of patients is critical (see Supplementary Table 2)