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It was hypothesized that their therapeutic effect may be due to the protection of neurons against the damage induced by excessive Ca 2+ levels ( Pramipexole, a D2/D3 agonist approved for the treatment of Parkinson's disease and restless legs syndrome, upregulates Bcl-2 (286)

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However, people who have used it say that generally, the general dosage is about 600mcg (micrograms) for an individual who weighs 60 kg or 132 lbs