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Dysregulation of the hypothalamuspituitarythyroid axis can contribute to hepatic metabolic disturbances, affecting lipid metabolism, glucose regulation and protein synthesis

Adding lifestyle interventions (exercise, heat therapy, targeted supplementation) creates additional BDNF support through independent pathways

Alcohol consumption in rats also decreases the levels of THTR-1 and THTR-2 in renal epithelial cells, thus limiting thiamin re-uptake by the kidneys (133)

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The cGPDH catalyses the conversion of dihydroxyacetone phosphate to glycerol-3-phosphate coupled with the oxidation of NADH to NAD +