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Biopolymers 32 , 523535 (1992)

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Safety-wise, no serious adverse events have been reported in short-term use, but long-term data is lacking 4

Tirzepatide is administered subcutaneously once weekly at doses ranging from 2.5 mg to 15 mg, with gradual dose escalation recommended to minimize gastrointestinal adverse effects

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Pharmacology of OR has been described with the message/address model: the ligand is composed of two parts, one carrying the activity (agonist or antagonist) at the different subtypes of OR, the message and one part, the address, conveying selectivity toward a given OR (Portoghese et al., 1990)