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North American studies, including the North American AIDS Cohort Collaboration on Research and Design (NAACCORD), demonstrate that HBV-HIV coinfection markedly elevates HCC risk compared with either infection alone, primarily through faster progression of liver fibrosis and cirrhosis and uncontrolled HBV replication (97)

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They represent a genuine paradigm shift in obesity treatment

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In SURMOUNT-1 , a 72-week Phase 3 double-blind trial in 2,539 adults with obesity (or overweight with a complication) but without diabetes, once-weekly tirzepatide produced mean weight changes of 15.0% (5 mg), 19.5% (10 mg), and 20.9% (15 mg) versus 3.1% with placebo, with 5057% of participants on the higher doses losing at least 20% of body weight

Experimental Gerontology 2004, 39 (2), 203-210