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For context on how these results compare with single-agonist options, semaglutide (Wegovy) achieved 14.9% mean weight loss at 68 weeks in the STEP 1 trial, and retatrutide , a triple agonist targeting GLP-1, GIP, and glucagon receptors, showed up to 24.2% weight loss in Phase 2
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A BMI of 29.5 and a BMI of 30.1 are clinically almost identical, but they sit on different sides of a regulatory line that changes everything about access and coverage
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