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Combining glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) in patients with type 2 diabetes mellitus (T2DM)
G-Actin Sequestration Mechanism Established , Foundational research characterising Thymosin Beta-4 biology established the G-actin sequestration mechanism that underlies TB-500s biological activity and with structural biology and biochemical studies documenting the direct binding between the Thymosin Beta-4 LKKTETQ actin-binding motif and monomeric G-actin, characterising the stoichiometry and affinity of this interaction, and establishing how Thymosin Beta-4-mediated G-actin sequestration regulates the dynamics of actin filament assembly and disassembly
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Neuroanatomy, Motor Neuron
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