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Cysteine is almost always the limiting piece, which is exactly what NAC supplies.[2]NAC as Antioxidant and Disulphide-Breaking Agent PubMed View source Because oral glutathione is poorly absorbed, giving the body cysteine through NAC is often a more reliable way to raise internal glutathione than taking glutathione itself

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Prior subclinical marrow failure is generally assumed in these situations, however subsequent proliferative mutations inside a PNH HSPC are another possibility (133)

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