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The drop in blood pressure is still a concern, and this medication must be used in a setting where treatment of the drop in blood pressure can be managed

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pyridine, CsOAc, 2,6-lutidine, DMAP, Na 2 CO 3 , DBU, DIPEA) was conducted and revealed that 2,6-lutidine gave the desired para -aminated product 5a in 53% yield

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