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Notably, Lu et al

Delaying administration by six hours shifts the peptide's distribution profile toward liver, adipose, and other non-muscle tissues where IGF receptors remain at baseline expression

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This is the primary clinical rationale for IV administration when therapeutic-level replenishment is the goal

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Using spatial transcriptomics, GPX4 has been identified to be located at the interface between the inner cortex and the outer medulla of the kidney, which is the main site of cell ferroptosis after I/R injury