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Tronnier, M., Rudolph, P., Kser, T., Raasch, B

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A recent pharmacokinetic study evaluating NAC confirmed that food intake significantly slows the absorption rate and reduces overall bioavailability, making fasting administration the preferred method for optimal clinical results

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One study with task-oriented and aerobic training showed no significant changes in VEGF or IGF-1, suggesting that disease severity or short intervention duration might blunt neurotrophic adaptation

Therefore, targeting TMAO may represent a promising therapeutic strategy for the treatment of kidney diseases