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The SEMALEAN study, published in 2025, tracked 115 semaglutide patients over 12 months using DEXA scans and found that while total lean mass initially declined, it stabilized by month 12 while fat mass continued dropping throughout

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A 500mcg daily protocol under split dosing would look like: 300mcg upon waking (fasted), then 200mcg approximately 30 minutes before dinner or before bed on an empty stomach

According to Novo Nordisk, some of the most common potential side effects of Wegovy include the following: Nausea Vomiting Stomach pain Diarrhea Constipation Gas Bloating Heartburn Upset stomach Dizziness Fatigue Sore throat Runny nose Stomach flu Allergic reaction While the above side effects are usually mild, consult your doctor if you experience severe pain, discomfort, or long-term side effects