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A recent systematic review indicated that while reductions in fat mass and visceral adipose tissue are generally consistent in obese or overweight adults, changes in lean mass are variable, showing decreases, preservation, or increases [49]

Lancet (1975) 1(7897):146

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In healthy individuals, SCFAs exert anti-inflammatory and neurotrophic effects by modulating histone acetylation, increasing brain-derived neurotrophic factor (BDNF) expression, and promoting regulatory T-cell development [20, 26]