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Immunomodulatory effects further contribute to their therapeutic potential: C
Increased fatigue was notable most among orforglipron, CagriSema, and naltrexone-bupropion No meaningful benefits in quality of life metrics were noted
Unlike semaglutide which only targets GLP-1 receptors, tirzepatides additional GIP receptor activity is thought to enhance insulin secretion, improve insulin sensitivity, and produce greater reductions in appetite and body weight
Cardiovascular outcome trial data for retatrutide have not been published
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