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For context, here's a clean comparison: Semaglutide 2.4 mg: ~15% body weight loss (68 weeks, Phase 3) Tirzepatide 15 mg: ~21% body weight loss (72 weeks, Phase 3) Retatrutide 12 mg: ~24% body weight loss (48 weeks, Phase 2) The trajectory is clear

J.et al (2016)

Severe GERD may present with respiratory symptoms including chronic cough, throat clearing, and a sensation of breathlessness, particularly when lying down

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In practical terms: Tirzepatide offers well-documented, steady metabolic support and weight-loss results

Therefore, the results and conclusions from these NAFLD-based trials remain relevant to MASLD populations