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GLP-1 receptor activation The GLP-1 component of retatrutide reduces appetite through multiple mechanisms: slowing gastric emptying (food stays in your stomach longer, so you feel full sooner), signaling satiety centers in the brain (your brain gets a stronger "stop eating" signal), and enhancing insulin secretion in response to meals

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These mechanisms have been observed across diverse models

Sci Rep (2021) 11:18522