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Unlike the cardiac samples, we observed several HFpEF-specific clusters in our UMAP, including a cluster of periportal-like hepatocytes (highlighted in Figure S7A-B ) and the cluster of proliferating cells that was significantly enriched in HFpEF in our cell type composition analysis ( Figure S7A, B )

The retrospective design introduces inherent biases, and the generalizability of our findings may be influenced by the characteristics of our study population