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These structural modifications significantly reduce IGF-1s binding affinity to IGF-binding proteins (IGFBPs), increasing the availability of the active peptide during in-vitro experimentation

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To test whether hepatic CYP8B1 plays a primary role in the regulation of glucose metabolism by T3, we performed a CYP8B1-knockdown experiment using adeno-associated virus (AAV) expressing shRNA specific for Cyp8b1

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