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Renal dysfunction, or reduced kidney function, is a common complication of MMA and may alter circulating metabolite profiles, particularly in pathways involved in arachidonic acid metabolism, redox homeostasis, mitochondrial energy metabolism, and NAD+ homeostasis

Under normal circumstances, hydrogen sulfide gets absorbed into the bloodstream in small amounts, metabolized by the liver, and eliminated without incident

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Current research priorities include large-scale studies to better understand the tissue-specific effects of NNMT inhibition and the temporal dynamics of metabolic reprogramming following treatment

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