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Management of anaphylactoid reactions is primarily supportive, with the first step being slowing or temporarily stopping the NAC infusion

2024;doi:10.1056/NEJMoa2403347) demonstrated that addition of semaglutide (Ozempic/Wegovy, Novo Nordisk) to an SGLT2 inhibitor showed no renal protective effect (HR = 1.07, 95% CI 0.69-1.67), although the number of subjects receiving an SGLT2 (16%) in this study was relatively small

Perivascular clustering of NG2-glia, particularly in active multiple sclerosis lesions, impairs their ability to appropriately separate from vessels following perivascular migration

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In pathological situations, these molecules can contribute to increased oxidative stress pathways and the over-synthesis of reactive oxygen species