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This threshold is aligned with the recent study published by Vallejo-Torres, which places the incremental cost per additional QALY between 27,000 and 34,000 [53], and has been commonly used in other cost-effectiveness publications in Spain

doi: 10.1017/S00 30, 31

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For typical titration-related constipation (less frequent but otherwise comfortable bowel movements), try home measures (Miralax daily, fiber, water, movement) for 1 to 2 weeks

[9] Ruggenenti P, Cattaneo D, Loriga G, Ledda F, Motterlini N, Gherardi G, Orisio S, Remuzzi G.Hypertension

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